Are you a healthy first generation Chinese male aged 18 to 55?

Have you ever wondered how new medicines are researched?

Be part of that development process.

Who we are

Richmond Pharmacology conducts medical research to help develop new medicines and improve current treatments available to patients. Our research unit, based at Croydon University Hospital in London, provides you with the safe and comfortable facilities.

What is this all about?

We are conducting a clinical research study of a new medicine being developed for slowing down the cell division and growth of cancer tumours. In this study we are testing the pharmacokinetics (PK) of the study medication (i.e. how it is distributed and broken down in the body) and pharmacodynamics (i.e. how effective it is) as well as the safety and tolerability in healthy male volunteers.

We will also compare the data from Japanese and non-Japanese Asian volunteers and we may take an exploratory pharmacogenomics (DNA) sample to see how variation in genetics may influence the data we obtain.

The trial is being conducted at Richmond Pharmacology Ltd only.

Who is suitable for this study?

To qualify for participation you need to:

Be a healthy first generation Chinese male aged between 18 and 55, inclusive, at screening.

By first generation Chinese we mean:

• • You were born in an Asian country other than Japan
  • You parents and grandparents (both maternal and paternal) are non-Japanese Asian
  • You are in possession of a valid passport from your country of origin
  • You have not lived outside your country of origin for longer than 5 years
• Be a non-smoker and or you have not been a smoker for a period of 3 months or more
• Weigh over 50 kg but not more than 100 kg, inclusive.
• Have a body mass index (BMI) between ≥18.5 and ≤30.0 kg/m² (inclusive) at screening. You can use this link to calculate your BMI: http://www.nhs.uk/tools/pages/healthyweightcalculator.aspx?WT.mc_id=101007
• Be willing to use acceptable contraceptive methods, avoid unprotected sex, and donating sperm until 3 months after treatment.

Other restrictions and exclusions apply – please ask for details.

Study Participation

This study is being conducted at our research facility at Croydon University Hospital in London. If you are interested in taking part you will need to contact us to register your interest. You would need to first attend a screening visit within 28 days before the start of the study. This is to make sure you are medically suitable to take part in the study. This would be Visit 1.

If you are medically suitable following your screening visit and you are still interested in taking part in this study you must be prepared to attend our clinical trials unit for 1 residential visit lasting 4 days and 3 nights (Visit 2) and final follow-up visit 7 days after the lost dose of the study medication. Your participation in this study will last roughly 5 weeks.

What do I receive if I decide to take part in this study?

Apart from helping medical research, you will also be paid for your time if you are included into the study.

You will receive £350 your time on completion of the study, once all results are confirmed, checked and deemed complete by the study doctor. You may be paid an additional payment of £180 as long as you meet the study requirements from start to finish, which include punctual attendance for appointments, being polite to staff and not bringing items into the clinical trials unit that you should not have with you at the time, such as other food and cigarettes. It should be noted that the bonus payment is at the discretion of Richmond Pharmacology Ltd. A full list of unit rules is available if you decide to attend a screening appointment.

The total amount that you could be paid for participation is £530. This includes all travel expenses.

Want to find out more?

If you are interested in finding out more click here to register / email [email protected] for details

Or

Call us on +44 (0)20 8664 5200 (choose option 1) and speak to a member of our Volunteer Recruitment Team.

A detailed information sheet is available on request.

The contents of this email have been approved by an ethics committee. Any response to this advertisement will be recorded.  Your response will not place you under any obligation to participate in this trial.

You may be required to remain resident in the unit until resolution of any safety issues, after which you will be discharged from the unit. 

您是健康的第一代日本人，或者是健康的第一代非日本亚洲人（如韩国人，中国人），并且年龄在 18-55 之间的男性么？

您是否曾经对新药如何研究出来的感到好奇吗？

来加入我们的新药研究中吧

自我介绍

里士满药理学 (Richmond Pharmacology) 有限公司将为医学研究开发新的药物，并为病患改善当前的医疗卫生条件。我们的研究地点设立在伦敦的克洛伊登大学医院 (Croydon University Hospital)，这里将为您提供安全舒适的设施。

试验内容是什么？

我们正在试验一种临床研究的新药，这新药将用于放缓癌症肿瘤细胞分裂和生长。在这项研究中，我们正在测试研究药物的药代动力学 (PK)（比如其是如何分布的及体内分解的）及药效性（比如它是如何的有效），同时还将观察健康的男性志愿者临床试验的安全性和耐药性。 

我们还将对日本和非日本的亚洲志愿者中的数据进行比较，我们可能需要一个探测性的药物基因组 (DNA) 样本，来观察遗传学上的变化，将可能如何影响我们得到的数据。

该实验仅在里士满药理有限公司 (Richmond Pharmacology Ltd) 进行。

哪些人适合参与此项研究？

您需要满足以下条件方可有资格参加本试验： 

• 在健康的第一代日本人，或是健康的第一代非日本亚洲人（如韩国人，中国人），年龄 18-55 岁之间筛选。所谓的第一代指的是:

 

• 出生地在中国, 台湾或香港

 

• 并且你的父母及祖父母(同时包括外祖父母)亦是来自同一个国家. 比如说, 你在中国出生, 你的父母, 祖父母和外祖父母都是出生于中国.

 

• 你拥有或拥有过有效的中国/台湾/香港护照

 

• 你没有在你的出生地之外居住超过5年.

 

• 不抽烟或者您至少已经戒烟 3 个月以上
• 体重在 50-100 公斤之间，包括 50 和 100 公斤。
• 在身材质量指数 (BMI) 从 18.5 到 30.0 kg/m2 之间（包含 18.5 和 30.0）筛选。您可以点击以下链接 BMI：http://www.nhs.uk/tools/pages/healthyweightcalculator.aspx?WT.mc_id=101007
• 愿意使用可接受的避孕方法，避免无保护的性行为，并在治疗 3 个月之后捐献精子。

如需了解更多其它限制和不适合条件，请联系我们获得更多信息。

参与研究

该研究将在伦敦的克莱伊登大学医院 (Croydon University Hospital) 研究机构进行。如果您有兴趣参加我们的研究，请联系我们并登记注册您的兴趣所在。首先，您需要在试验开始之前 28 天内参加一次筛选。这次筛选可确定您是否符合本次研究。这将是先决条件。

如果您满足先决条件而且您还有兴趣参与本研究，您将必须参加我们的临床试验项目，即临床持续观察 4 天 3 夜（第二条件）。最后在试验药物停用后还要一个后续的7天观察。您的参与试验时间大约持续 5 周。

如果我决定参加这项研究我将得到什么？

如果您参与本次研究，您将不仅帮助医学研究，还会获得一定的报酬。

所有的实验数据经过本次的研究医生确认，检查并评估完成后，您将被认为完成本研究，并获得 350 英镑的报酬。如果您满足以下条件，您将获得另外 180 英镑报酬：准时参与研究，礼待员工，不在临床试验时带上不合规定的物品，如食品和香烟。在此应该指出，里士满药理学有限公司有权酌情给出报酬。如果您确定要参加筛选预约，我们将提供实验管理条例。

您可能得到的报酬总额为 530 英镑，包含路费在内。包含路费在内。

想了解更多么？

如果您有兴趣了解更多信息，请点击这里注册/电子邮件  [email protected]来获得更多信息。

或

联系我们：+44 (0)20 8664 5200（选择选项 1），并将您的问题告知我们的志愿招募小组成员。

应要求我们还提供详细的信息表。

本电子邮件内容经过伦理委员会的审核。任何对本广告的回应都将被记录。您不须因您的回应在参加本次试验中承担任何责任。

在相关安全问题解决之前，您可能需要留在实验室中居住，在这之后，您就可以离开实验室。